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TIME: Almanac 1995
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1995-02-24
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<text id=93TT1048>
<title>
Mar. 01, 1993: AIDS Triple Play
</title>
<history>
TIME--The Weekly Newsmagazine--1993
Mar. 01, 1993 You Say You Want a Revolution...
</history>
<article>
<source>Time Magazine</source>
<hdr>
THE WEEK, Page 16
HEALTH & SCIENCE
AIDS Triple Play
</hdr>
<body>
<p>Researchers hit on a new chemical combination to combat the virus
</p>
<p> It is not a cure. It is not even a treatment yet. But preliminary
research, revealed in Nature, points to a new way to attack
the AIDS virus. By targeting a single phase in the virus' life
cycle with three drugs, Yung-Kang Chow and his colleagues at
Massachusetts General Hospital found that they could stop the
infection cold--in the test tube anyway.
</p>
<p> Operating alone, each of the three drugs--AZT, ddI and pyridinone--merely slows down the virus' ability to reproduce. Eventually,
the microbe mutates and becomes resistant to treatment. Chow's
triple combo, however, appears to overwhelm HIV's ability to
develop into new strains. More than a month after the scientists
stopped treatment of their laboratory cultures, they could find
no virus.
</p>
<p> This spring researchers will try out the combination therapy
on 200 volunteer patients. Chow's approach could still wind
up on the dustheap of medical history; numerous treatments that
looked promising in the laboratory failed miserably in the clinic.
Even if it works, the triple-dose treatment cannot eradicate
virus particles that have already tunneled their way into human
chromosomes. However, Chow's approach might transform AIDS into
a more manageable chronic condition.
</p>
</body>
</article>
</text>